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Most powerful obesity drug yet?

 Posted 15 December 2025 AM

Eli Lilly’s triple agonist retatrutide is on track to become the most effective obesity treatment on the market, after recording outstanding weight-loss results in a phase 3 trial, as well as reducing knee pain from arthritis.

However, those results were offset by a higher discontinuation rate than in previous studies, and an unusual adverse effect: dysesthesia, or unpleasant skin sensations, which affected about one in five patients taking the higher dose.

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