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Local coders drive JAK discovery
Posted 10 December 2025 AM
A JAK inhibitor without a dose-limiting side effect is on the cards thanks to powerful quantum chemistry simulations developed by Australian researchers that identified a highly specific target site.
The drug is so promising that its developer, Prelude, signed an option agreement with Incyte for the latter to acquire the program in November, receiving US$35 million up front and a US$25 million strategic equity investment. A further US$100 million is payable if Incyte exercises its option, and up to US$775 million in additional potential milestones plus royalties on net sales.
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Posted 10 December 2025 AM
A JAK inhibitor without a dose-limiting side effect is on the cards thanks to powerful quantum chemistry simulations developed by Australian researchers that identified a highly specific target site.
The drug is so promising that its developer, Prelude, signed an option agreement with Incyte for the latter to acquire the program in November, receiving US$35 million up front and a US$25 million strategic equity investment. A further US$100 million is payable if Incyte exercises its option, and up to US$775 million in additional potential milestones plus royalties on net sales.
To see the whole article, please login
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