Is this popular drug on thin ice?

 Posted 30 September 2025 PM

Makers of the P2Y12 inhibitor clopidogrel will be hoping for a change in clinical guidelines and a big leap in sales after a study showed it to be a more effective blood thinner than aspirin.

The meta-analysis of seven randomised trials, involving almost 29,000 patients, compared clopidogrel monotherapy with aspirin monotherapy in patients with established coronary artery disease (CAD) who had discontinued or never started dual antiplatelet therapy (a P2Y12 inhibitor in combination with aspirin).